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Ginseng for hair loss?
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Thread: Ginseng for hair loss?
05-09-2021, 07:40 AM
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#1
Ginseng for hair loss?
https://www.spandidos-publications.c...?text=abstract
August 25, 2017 It is well known that Panax ginseng (PG) has various pharmacological effects such as anti-aging and anti-inflammation. In a previous study, the authors identified that PG extract induced hair growth by means of a mechanism similar to that of minoxidil. In the present study, the inhibitory effect of PG extract on Dickkopf-1 (DKK-1)-induced catagen-like changes in hair follicles (HFs) was investigated in addition to the underlying mechanism of action. The effects of PG extract on cell proliferation, anti-apoptotic effect, and hair growth were observed using cultured outer root sheath (ORS) keratinocytes and human HFs with or without DKK-1 treatment. The PG extract significantly stimulated proliferation and inhibited apoptosis, respectively, in ORS keratinocytes. PG extract treatment affected the expression of apoptosis-related genes Bcl-2 and Bax. DKK-1 inhibited hair growth, and PG extract dramatically reversed the effect of DKK-1 on ex vivo human hair organ culture. PG extract antagonizes DKK-1-induced catagen-like changes, in part, through the regulation of apoptosis-related gene expression in HFs. These findings suggested that PG extract may reduce hair loss despite the presence of DKK-1, a strong catagen inducer via apoptosis.
August 25, 2017 It is well known that Panax ginseng (PG) has various pharmacological effects such as anti-aging and anti-inflammation. In a previous study, the authors identified that PG extract induced hair growth by means of a mechanism similar to that of minoxidil. In the present study, the inhibitory effect of PG extract on Dickkopf-1 (DKK-1)-induced catagen-like changes in hair follicles (HFs) was investigated in addition to the underlying mechanism of action. The effects of PG extract on cell proliferation, anti-apoptotic effect, and hair growth were observed using cultured outer root sheath (ORS) keratinocytes and human HFs with or without DKK-1 treatment. The PG extract significantly stimulated proliferation and inhibited apoptosis, respectively, in ORS keratinocytes. PG extract treatment affected the expression of apoptosis-related genes Bcl-2 and Bax. DKK-1 inhibited hair growth, and PG extract dramatically reversed the effect of DKK-1 on ex vivo human hair organ culture. PG extract antagonizes DKK-1-induced catagen-like changes, in part, through the regulation of apoptosis-related gene expression in HFs. These findings suggested that PG extract may reduce hair loss despite the presence of DKK-1, a strong catagen inducer via apoptosis.
05-09-2021, 07:55 AM
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#2
05-09-2021, 07:58 AM
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#3
Can you outline the mechanism of androgenic hair loss?
AR with relatively high affinity for DHT leading to downstream death of hair follicles.
Does this stop an intermediate step?
Does it simply improve the appearance during loss, like rogaine?
Does it systemically disturb androgen signalling?
AR with relatively high affinity for DHT leading to downstream death of hair follicles.
Does this stop an intermediate step?
Does it simply improve the appearance during loss, like rogaine?
Does it systemically disturb androgen signalling?
05-09-2021, 08:01 AM
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#4
05-09-2021, 08:19 AM
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#5
Originally Posted By merb0⏩
DHT activates DKK-1, which strongly inhibits hair growth (which looks to be driven by Wnt/B-catenin).Can you outline the mechanism of androgenic hair loss?
AR with relatively high affinity for DHT leading to downstream death of hair follicles.
Does this stop an intermediate step?
Does it simply improve the appearance during loss, like rogaine?
Does it systemically disturb androgen signalling?
AR with relatively high affinity for DHT leading to downstream death of hair follicles.
Does this stop an intermediate step?
Does it simply improve the appearance during loss, like rogaine?
Does it systemically disturb androgen signalling?
Dickkopf-1 (DKK-1), which is a potent antagonist of the Wnt/β-catenin signaling pathway, is inducible by dihydrotestosterone (DHT) and promotes catagen progression and the apoptotic cell death of HFs (11). Kwack et al (12,13) demonstrated that DKK-1 is secreted from hDPCs in response to DHT and that it promotes the regression of HFs by blocking Wnt/β-catenin signaling and by inhibiting the growth of ORS keratinocytes and triggering apoptotic cell death.
Not sure on the systematic effects. Ginseng taken normally is systematic. This was a "ex vivo" study or done outside the body in a scientific environment. Not sure if the effects translate. Ginseng does have quite a few systematic effects that are positive as far as cancer and general health. I don't know if this would be applied topically, my guess is yes. They compared it to minoxidil (aka rogaine) in how it works so that is more towards topical I'm thinking.
05-09-2021, 08:21 AM
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#6
- backinthegymbro
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- backinthegymbro
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Reminds me of this guy on youtube who used natural products against his hairloss. Dude was like a norwood 100.
In the end there's finasteride and hair transplants. If the reaper is coming, there is no alternative.
In the end there's finasteride and hair transplants. If the reaper is coming, there is no alternative.
Cobra Kai never dies!
05-09-2021, 08:30 AM
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#7
05-09-2021, 08:38 AM
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#8
Originally Posted By backinthegymbro⏩
I'm thinking people can also try and walk back on DHT naturally. Lower bf to keep testosterone up (dht seems to come out more when fat rises), not quite as heavy of weight... 80% of 1-rep max or so to go after that slow twitch fat burning muscle type rather than glycolytic fast twitch max strength fibers.Reminds me of this guy on youtube who used natural products against his hairloss. Dude was like a norwood 100.
In the end there's finasteride and hair transplants. If the reaper is coming, there is no alternative.
In the end there's finasteride and hair transplants. If the reaper is coming, there is no alternative.
Originally Posted By merb0⏩
Minox only works in 20-40% of people. Otherwise its great for hairDoes min do the same thing?
If so, why do people bother with 5AR at all? Incomplete inhibition of the pathways?
A drug more tailored to this mechanism makes more sense, though ginseng seems well-tolerated.
If so, why do people bother with 5AR at all? Incomplete inhibition of the pathways?
A drug more tailored to this mechanism makes more sense, though ginseng seems well-tolerated.
05-09-2021, 09:14 AM
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#9
- Realityy
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- Realityy
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FYI, a metabolite of vitamin C also inhibits DKK
https://pubmed.ncbi.nlm.nih.gov/21034532/
https://pubmed.ncbi.nlm.nih.gov/21034532/
In a previous study, we recently claimed that dihydrotestosterone (DHT)-inducible dickkopf-1 (DKK-1) expression is one of the key factors involved in androgen-potentiated balding. We also demonstrated that L-ascorbic acid 2-phosphate (Asc 2-P) represses DHT-induced DKK-1 expression in cultured dermal papilla cells (DPCs). Here, we investigated whether or not L-threonate could attenuate DHT-induced DKK-1 expression. We observed via RT-PCR analysis and enzyme-linked immunosorbent assay that DHT-induced DKK-1 expression was attenuated in the presence of L-threonate. We also found that DHT-induced activation of DKK-1 promoter activity was significantly repressed by L-threonate. Moreover, a co-culture system featuring outer root sheath (ORS) keratinocytes and DPCs showed that DHT inhibited the growth of ORS cells, which was then significantly reversed by L-threonate. Collectively, these results indicate that L-threonate inhibited DKK-1 expression in DPCs and therefore is a good treatment for the prevention of androgen-driven balding.
05-09-2021, 09:24 AM
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#10
- teodorkanev1
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- teodorkanev1
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Lol cya later losers, I'mma go out buy some ginseng and Vitamin C and hairmaxx
Can't wait to LMFAO at baldcels again
Can't wait to LMFAO at baldcels again
Pittsburgh Penguins 5x Stanley Cup Champions
AMG Petronas 9x Drivers' Championships, 7x Constructors' Championship
05-09-2021, 11:20 AM
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#11
Originally Posted By Realityy⏩
Looks like it works via IGF-1. Probably have to be topically appliedhttps://pubmed.ncbi.nlm.nih.gov/19416266/
05-09-2021, 11:26 AM
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#12
05-09-2021, 04:25 PM
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#13
NAC might be the next big thing for hair
Abstract
Elevated levels of prostaglandin D2 (PGD2) have been shown to be present in the bald scalp of androgenic alopecia (AGA) patients and to functionally inhibit hair growth. However, its precise mechanism in AGA has yet to be clearly defined. Although testosterone plays a critical role in the initiation and progression of AGA, the existence of a possible link between PGD2 and testosterone in skin has not been investigated. Here we show that human keratinocytes treated with PGD2 show enhanced capacity to convert the weak androgen, androstenedione, to testosterone. At the same time, treatment with PGD2 induced reactive oxygen species as indicated by generation of the lipid peroxidation product, 4-hydroxynonenal. To determine whether these two events are linked, we used the reactive oxygen species scavenger N-acetyl-cysteine, which blocked the enhanced testosterone production from PGD2-treated keratinocytes. Our study suggests the existence of a possible crosstalk between the PGD2-reactive oxygen species axis and testosterone metabolism in keratinocytes. Thus, we propose that AGA patients might benefit from the use of N-acetyl-cysteine or other antioxidants as a supplement to currently available or emerging AGA therapies such as finasteride, minoxidil, and PGD2 receptor blockers.
https://pubmed.ncbi.nlm.nih.gov/28941500/
Abstract
Elevated levels of prostaglandin D2 (PGD2) have been shown to be present in the bald scalp of androgenic alopecia (AGA) patients and to functionally inhibit hair growth. However, its precise mechanism in AGA has yet to be clearly defined. Although testosterone plays a critical role in the initiation and progression of AGA, the existence of a possible link between PGD2 and testosterone in skin has not been investigated. Here we show that human keratinocytes treated with PGD2 show enhanced capacity to convert the weak androgen, androstenedione, to testosterone. At the same time, treatment with PGD2 induced reactive oxygen species as indicated by generation of the lipid peroxidation product, 4-hydroxynonenal. To determine whether these two events are linked, we used the reactive oxygen species scavenger N-acetyl-cysteine, which blocked the enhanced testosterone production from PGD2-treated keratinocytes. Our study suggests the existence of a possible crosstalk between the PGD2-reactive oxygen species axis and testosterone metabolism in keratinocytes. Thus, we propose that AGA patients might benefit from the use of N-acetyl-cysteine or other antioxidants as a supplement to currently available or emerging AGA therapies such as finasteride, minoxidil, and PGD2 receptor blockers.
https://pubmed.ncbi.nlm.nih.gov/28941500/
05-09-2021, 04:34 PM
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#14
reaper sits patiently knowing his time is near
maybe you should clean up your diets srs
just because everyone has a morning coffee doesn't mean its healthy
Alot of chit foods dont initially cause pain yet they are hard at work deteriorating your health from the inside out
maybe you should clean up your diets srs
just because everyone has a morning coffee doesn't mean its healthy
Alot of chit foods dont initially cause pain yet they are hard at work deteriorating your health from the inside out
05-09-2021, 04:44 PM
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#15
Seems weak.
This only says elevated prostaglandins increase test from converting another steroid, and antioxidant treatment stopped this, presumably in virto. Probably they dosed it stupidly.
Regardless, prostaglandins and normal testosterone remained.
ROS might affect the pathway, and antioxidant treatments might work. I doubt it. I do not know the full mechanism.
I also doubt most of the androgens in the scalp come from androstendenione converted in skin cells to testosterone, or topical antioxidant application stopping this.
This only says elevated prostaglandins increase test from converting another steroid, and antioxidant treatment stopped this, presumably in virto. Probably they dosed it stupidly.
Regardless, prostaglandins and normal testosterone remained.
ROS might affect the pathway, and antioxidant treatments might work. I doubt it. I do not know the full mechanism.
I also doubt most of the androgens in the scalp come from androstendenione converted in skin cells to testosterone, or topical antioxidant application stopping this.
05-09-2021, 05:24 PM
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#16
Originally Posted By merb0⏩
Its like cryptos, throw $25 here and there and hope it does somethingSeems weak.
This only says elevated prostaglandins increase test from converting another steroid, and antioxidant treatment stopped this, presumably in virto. Probably they dosed it stupidly.
Regardless, prostaglandins and normal testosterone remained.
ROS might affect the pathway, and antioxidant treatments might work. I doubt it. I do not know the full mechanism.
I also doubt most of the androgens in the scalp come from androstendenione converted in skin cells to testosterone, or topical antioxidant application stopping this.
This only says elevated prostaglandins increase test from converting another steroid, and antioxidant treatment stopped this, presumably in virto. Probably they dosed it stupidly.
Regardless, prostaglandins and normal testosterone remained.
ROS might affect the pathway, and antioxidant treatments might work. I doubt it. I do not know the full mechanism.
I also doubt most of the androgens in the scalp come from androstendenione converted in skin cells to testosterone, or topical antioxidant application stopping this.
Not that I do cryptos... throwing away money on hairloss treatments is money better wasted
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