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Β» SARS-CoV-2 breakthrough infections in vaccinated individuals
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post 1653106523 12-24-2021, 10:36 AM
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SARS-CoV-2 breakthrough infections in vaccinated individuals

A nicely written and fairly comprehensive discussion:

"We argue that, rather than trying to tease apart the contributions of factors such as age, viral variants and time since vaccination, the rates of breakthrough infection are best seen as a consequence of the level of immunity at any moment in an individual, the variant to which that individual is exposed and the severity of disease being considered. We also address key open questions concerning the transition to endemicity, the potential need for altered vaccine formulations to track viral variants, the need to identify immune correlates of protection, and the public health challenges of using various tools to counter breakthrough infections, including boosters in an era of global vaccine shortages."

"In this Perspective, we first describe the approaches used to measure breakthrough infections and then consider the causes and impact of these breakthrough infections. Finally, we discuss some of the critical questions that remain to be addressed concerning breakthrough infections."

https://www.nature.com/articles/s41577-021-00662-4
post 1653106803 12-24-2021, 10:41 AM
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Paging Anachron...
post 1653106983 12-24-2021, 10:44 AM
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Post deleted by user
Original Ruckus
post 1653107163 12-24-2021, 10:46 AM
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Still waiting patiently for you to go back in your other thread and admit you were wrong about the omicron variant being as severe as others.
post 1653107323 12-24-2021, 10:48 AM
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I'll breakthrough their butthole
post 1653107483 12-24-2021, 10:50 AM
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Originally Posted By jtaylor2010
Still waiting patiently for you to go back in your other thread and admit you were wrong about the omicron variant being as severe as others.
The authors said they didn't have evidence omicron was less severe. This is a different article from different authors. I'm not on author on this one or the other one.
post 1653107903 12-24-2021, 10:54 AM
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Originally Posted By SuperHercules
Stopped reading at "breakthrough infections"
This. "Breakthrough" is the wording of big pharma shills downplaying how often this occurs. We already have a words that more accurately describe something that doesn't work as intended like ineffective and failure.
post 1653107953 12-24-2021, 10:55 AM
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#8
  1. steeler505
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Breakthrough insinuates there was something in the way in the first place lmaoo
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post 1653108653 12-24-2021, 11:04 AM
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"No vaccine is perfectly effective, even those against yellow fever, which seem to be very close1. For a virus like severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), sterilizing immunity is difficult to achieve, even with vaccines, and protection is expected to decline with time since vaccination2. Therefore, the key questions for scientists studying breakthrough infections β€” a term used to describe infections in fully vaccinated people β€” surround their timing, frequency, causes, severity and levels of infectiousness."

"...if breakthrough infections are common, severe or highly transmissible, then there may be a need for additional vaccine doses, changes in vaccine formulations or non-pharmaceutical interventions (or a combination of these approaches) to reduce the incidence of infection"

"Measuring vaccine effectiveness is challenging for several reasons. Given the substantial burden of infection before vaccines became available, some individuals who are unvaccinated will nonetheless have some immunity as a result of prior infection, complicating comparisons of immunity between these groups (although there are approaches to account for this complexity). Additionally, SARS-CoV-2 infection has a spectrum of disease severity from asymptomatic to fatal, and vaccine effectiveness against each outcome may be different."
post 1653108863 12-24-2021, 11:07 AM
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#10
  1. J.L.C.
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"Vaccines against viruses work by generating immune responses that inhibit the infection process (mainly serum antibodies that bind and/or neutralize virus particles and, for mucosally applied vaccines, also mucosal secretory IgA) and by creating immune memory in the form of antigen-specific memory B cells and T cells that are primed to produce a rapid anamnestic response when the infection reintroduces the vaccine antigen into the body.

These mechanisms can prevent initial proliferation of the virus or, failing that, rapidly control it, reducing the amount of virus to which the host is ultimately exposed and the duration of the exposure. While the amount of circulating antibody present following vaccination (or any antigenic stimulus) increases rapidly, on a timescale of days to weeks, it also declines rapidly from its peak on a timescale of weeks to months, and then more slowly over a time scale of decades.

The first phase reflects antibody secreted by short-lived plasmablast populations, which expand right after antigen exposure as a first line of defense. They typically die within 1–2 weeks after antigen exposure and the antibody they secreted declines based on the specific antibody half-life (approximately 21 days for IgG).

The second, usually very slow, phase of decline likely reflects the kinetics of long-lived plasma cells, which migrate to the bone marrow and from there secrete antibody into the blood, often maintaining stable titres for many years.

Importantly, although peripherally injected vaccines can induce low levels of IgG and monomeric IgA antibodies at the mucosal surfaces of the upper respiratory tract (which are the main entry portal for respiratory viruses) they do not induce secretory IgA efficiently. The small proportions of IgG and IgA that land on the mucosal surfaces of the upper respiratory tract after intramuscular vaccination disappear relatively quickly as serum antibodies wane."
post 1653109093 12-24-2021, 11:10 AM
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#11
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Originally Posted By Anachron


It's now become a pandemic of the vaccinated. Time to lock them all down. Can't phucking believe they would travel to Cancun, come back and kill grandma. Selfish and utterly trash human beings.
positivity brah crew
dont take my posts too srs crew srs
JFL @ everything crew
lol @ tradies srs crew
BIG LOL @ sky tradies srs crew (RealAesthetic)
indian crew
living in clown world crew so screw it crew
anti-degen crew
post 1653109263 12-24-2021, 11:12 AM
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Originally Posted By Anachron


you have to
post 1653109303 12-24-2021, 11:12 AM
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Originally Posted By Anachron
If you want to change the topic, can you let us know what those data represent? Is that global data?
post 1653109333 12-24-2021, 11:13 AM
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Originally Posted By J.L.C.
If you want to change the topic, can you let us know what those data represent? Is that global data?
always be a cnt mate ...never change
post 1653109383 12-24-2021, 11:13 AM
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Originally Posted By AncientYouth
always be a cnt mate ...never change
I thought you had me on ignore?
post 1653109493 12-24-2021, 11:15 AM
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"Whether a breakthrough infection occurs when a vaccinated host is exposed to an infectious person depends on whether the immune response present in that person at the moment of exposure is sufficient to abort or rapidly control the infection:



Given the kinetics of immune responses, it is not surprising that the amount of protection offered by a vaccine against infection might decline over time, allowing more breakthrough infections as the immune response wanes over months (as observed for influenza virus vaccines) and/or as immune memory wanes over years (as observed for mumps vaccines).

Likewise, protection might increase after a breakthrough infection or after a subsequent vaccine dose, which enhances the person’s immune response. It is also unsurprising that older individuals, whose neutralizing antibody responses to COVID-19 vaccines are typically lower, appear to be at greater risk of breakthrough infections at any given time following vaccination"
post 1653109503 12-24-2021, 11:15 AM
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#17
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Lmao. That new line chart is the absolute vax mogger. Thanks anachron.
post 1653109513 12-24-2021, 11:16 AM
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Not sure why we're still calling them "breakthrough", we all know the vaccine is is worthless and only benefits pharmaceutical companies
Yellow fever crew
High test Manlet crew
EE master race

5'7" @ 175
PRs, B325 S405 D405
post 1653109563 12-24-2021, 11:16 AM
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#19
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Originally Posted By Anachron
You know what that data is and where it came from.

Stop being so dishonest.
It's an imgur link.
post 1653109863 12-24-2021, 11:20 AM
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Things really seem vary by location:



https://health-infobase.canada.ca/co...-19-cases.html
post 1653109873 12-24-2021, 11:20 AM
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Originally Posted By J.L.C.
The authors said they didn't have evidence omicron was less severe. This is a different article from different authors. I'm not on author on this one or the other one.
Thats why we used to wait for more data. Creating, implementing, and mandating before data is available leads to medical reversal. Its the reason why the top 2 members of the FDA have recently resigned.
post 1653109943 12-24-2021, 11:21 AM
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#22
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Originally Posted By Anachron
So you're saying you don't think it's trustworthy?
Just asking what the data are. Imgur is image hosting.
post 1653110153 12-24-2021, 11:24 AM
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[QUOTE=Anachron post_id=1653109953]Old data, almost three weeks out of date.

[img]https://i.imgur.com/RCf8CUM.jpg[/ig]

[img]//assets.bodybuilding.com/forum/images/smilies/biggrin.gif[/img][/QUOTE]What does fauci say when the vaxxed rate is[i]higher[/i]than unvaxxed?

Cant wait for that zoom interview.
post 1653110373 12-24-2021, 11:26 AM
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#24
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Originally Posted By Anachron
I'm waiting for the data the be "retracted" or "modified" so it suits the narrative better.

Hence why I screenshotted and saved.
Where's it from?

Nevermind, found it:

https://covid-19.ontario.ca/data
post 1653110903 12-24-2021, 11:33 AM
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Why didn't you share the age breakdowns?

















Source:https://covid-19.ontario.ca/data
post 1653111143 12-24-2021, 11:36 AM
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Originally Posted By J.L.C.
Why didn't you share the age breakdowns?

Omg.... 4 in 100,000 children are catching this obscenely mild cold? Disgusting that anyone would be questioning vax mandates of the 5-11 population.
post 1653111203 12-24-2021, 11:37 AM
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#27
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Originally Posted By Anachron
Old data, almost three weeks out of date.



I feel like this line chart exists because all of the vax-cels have been locked down and hiding this entire time. Now that they are all jabbed and things are reopening in their areas they are venturing out into public more and more and are discovering that the vaccine is worthless and they will get covid at the same rate as unvaccinated people.


There is a reason why the most locked down/strict places are having the biggest issues right now.


City I live in has been wide open for over a year now. Maybe 60% of people vaxxed. TBH if I wouldn't log onto the misc and social media I really wouldn't hear/read anything about covid. Nobodys talking about it or thinking about it here. Omnicron exists but it seems to be so incredibly mild its not even worth concerning yourself over.




Went over to a friends house about 2 weeks ago. They had covid. 8 of us there. No masks or 'social distancing' but the sick brah made an effort to stay 6-8 ft away. Nobody was really worried. Nobody got covid either. All unvaxed EXCEPT the brah with Covid who was vaxed and boosted because of work.




Its nearly 2022. If your still alive I think your genes are probably good enough.
post 1653111293 12-24-2021, 11:39 AM
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#28
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Originally Posted By Anachron
Thanks for confirming you knew exactly where it came from, but acted dumb.



I had to search since you refused to share the source. But now I can see why you didn't want to reveal where it came from.
post 1653111423 12-24-2021, 11:41 AM
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#29
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Originally Posted By HMFIC_BROWSIN
Omg.... 4 in 100,000 children are catching this obscenely mild cold? Disgusting that anyone would be questioning vax mandates of the 5-11 population.
Not sure where you're seeing discussion of mandates. Mandates certainty weren't the intended discussion topic of the thread.
post 1653111553 12-24-2021, 11:42 AM
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#30
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went out for dinner with 13 fellas, 4 reported getting COVID a couple of days later .......all triple jabbed
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