A Systematic Review of Persistent Clinical Features After SARS-CoV-2 in the Pediatric Population

"OBJECTIVE
To present the prevalence and characteristics of the long-term clinical features of COVID-19 (long COVID) in the global pediatric population.

RESULTS
Twenty seven cohorts and 4 cross-sectional studies met the inclusion criteria and involved over 15 000 pediatric participants. A total of more than 20 persistent symptoms and clinical features were reported among children and adolescents. 16.2% (95% confidence interval 8.5% to 28.6%) of the pediatric participants experienced 1 or more persistent symptom(s) at least 3 months post COVID-19. Female gender might be associated with developing certain long COVID symptoms.

CONCLUSIONS
Persistent clinical features beyond 3 months among children and adolescents with proven COVID-19 are common and the symptom spectrum is wide. High-quality, prospective studies with proper controls are necessary in the future."

https://publications.aap.org/pediatr...stent-Clinical

They used regression developed byComprehensive Meta-analysis version 2.2.027. They did not specify who supervised the regression.

"FUNDING: Unrestricted support for this review was provided by a grant from UNICEF (New York) through the International Pediatric Association with additional core support from the Centre for Global Child Health, Toronto. The sponsor did not participate in the work."

"CONFLICT OF INTEREST DISCLOSURES: The authors have indicated they have no conflicts of interest relevant to this article to disclose."

OP be like..

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However, the majority of these studies conducted their follow-ups by contacting the participants regularly, eg, monthly or quarterly, instead of using a “real-time” reporting system or platform that the participants could report their symptoms actively and reasonably quickly, hence leaving open the potential of some recall bias.


Furthermore, the definition of “long COVID” in the pediatric group is still vague. A large number of studies defined long COVID by clinical features persisting for at least 1-month postinfection and lacked follow-up data of a longer duration. Most reported studies also did not systematically collect information on laboratory features among evaluated children, and the latter information was mainly restricted to hospitalized children. While conducting this systematic review, we found that studies of long COVID in the pediatric population with a follow-up of at least 3 months for analysis only accounts for a third of the total studies on this topic. Within our included studies, only some of them clearly described the duration of each symptom during follow-up and they did not report new onset symptoms and persistent symptoms separately. The limited number of studies with sufficient follow-up length and data, as well as the considerable heterogeneity observed among studies, made it challenging to pool these data and estimate the prevalence and symptom spectrum of long COVID in the pediatric population. Therefore, our conclusions should be interpreted with caution.


Recently, recurrent infection of SARS-CoV-2 has become increasingly common because of the emergence of new variants. Other viral infections are also common. The majority of current studies did not collect or provide information related to other concurrent viral infection during follow-up, nor did they take recurrent COVID-19 into consideration. Establishing the relationship between “new, persistent, and/or recurring” symptoms during follow-up and previous SARS-CoV-2 infection remains a big challenge for long COVID studies.






But by all means, please keep getting your boosters if you want to Opie.

Etchu Dr. Fauci?

But I'm not a kid and this study wasn't about vaccines.

Are these results typical of the common cold/sniffles?

Oh come now! What's a little Rona without some hot delicious Fauci Fluid?

No, not that list after 3 months.
That bar graph showed a lot of variability among kids.

A fever for 3+ months can't be good.