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Forum » Long Covid Metabolites 2-years Post-Infection
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Thread: Long Covid Metabolites 2-years Post-Infection

post 1687655273 08-02-2023, 02:08 PM
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Long Covid Metabolites 2-years Post-Infection

The plasma metabolome of long COVID patients two years after infection

" A targeted metabolomics approach using a combination of LC–MS/MS and FIA MS/MS was performed to quantify 108 metabolites. IL-17 and leptin were measured in long COVID patients by immunoenzymatic assay.

The comparison of paired COVID-19/long COVID-19 samples revealed 53 metabolites that were statistically different. Compared to controls, 27 metabolites remained dysregulated even after two years. Post-COVID-19 patients displayed a heterogeneous metabolic profile. Lactic acid, lactate/pyruvate ratio, ornithine/citrulline ratio, and arginine were identified as the most relevant metabolites for distinguishing patients with more complicated long COVID evolution.

Additionally, IL-17 levels were significantly increased in these patients. Mitochondrial dysfunction, redox state imbalance, impaired energy metabolism, and chronic immune dysregulation are likely to be the main hallmarks of long COVID even two years after acute COVID-19 infection."

https://www.nature.com/articles/s41598-023-39049-x

Analyses were done with Metabolite Set Enrichment Analysis (MSEA) and Metabolomic Pathway Analysis (MetPA) modules as found in MetaboAnalyst 5.08 (https://www.metaboanalyst.ca/, Canadian company)

Data are freely available, link in paper.

Funding:
CONACyT grant number 311880 “Identificación y validación de marcadores inmuno-metábolicos que incrementan la suscpetibilidad a desarrollar formas graves de infección por SARS-CoV-2”. CONACyT grant number 319503 “Tamizaje masivo de pequeñas moléculas para la identificación de biomarcadores y candidatos terapéuticos con alto potencial de efectividad contra nuevas variantes de SARS-CoV-2 circulantes a nivel mundial”. Christus Muguerza del Parque Hospital, Chihuahua, Mexico. Instituto Mexicano de Seguridad Social. Genome Alberta (a division of Genome Canada) grant number TMIC MC4, the Canadian Institutes of Health Research (CIHR) grant number FS 148461, the Canada Foundation for Innovation (CFI) grant number MSIF 35456.

Authors declared no conflicts of interest.
post 1687656133 08-02-2023, 02:23 PM
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OP, you can't get unvaccinated, stop trying to convince yourself you did the right thing, just move on...
Would kick em in the nuts
post 1687656263 08-02-2023, 02:25 PM
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Originally Posted By Antoine99⏩
OP, you can't get unvaccinated, stop trying to convince yourself you did the right thing, just move on...
How does this study related to vaccines or vaccination? Can you get uninfected?
post 1687656653 08-02-2023, 02:33 PM
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Originally Posted By J.L.C.⏩
How does this study related to vaccines or vaccination? Can you get uninfected?
What he wrote went over your head.

Also, you're searching for attention. Nobody cares, including MDs.
Yeah Buddyyy! Light weight! Light weight baby!!!!
post 1687657103 08-02-2023, 02:41 PM
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Originally Posted By frankdtank20⏩
What he wrote went over your head.

Also, you're searching for attention. Nobody cares, including MDs.
Interesting (fallacious) points!
post 1687657383 08-02-2023, 02:48 PM
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Yep, the original Covid was terrible. Time to hold China accountable for their horribly irresponsible actions which resulted in all this suffering across the globe.
post 1687657513 08-02-2023, 02:50 PM
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Originally Posted By J.L.C.⏩
The plasma metabolome of long COVID patients two years after infection
Another covid thread?

It's a hot night. The mind races. You think about your knife: the only friend who hasn't betrayed you, the only friend who won't be dead by sunup. Sleep tight mates, in your quilted chambray night shirts.
post 1687657523 08-02-2023, 02:50 PM
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Lol
In Hoots We Trust.
post 1687657843 08-02-2023, 02:56 PM
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Originally Posted By jtaylor2010⏩
Yep, the original Covid was terrible. Time to hold China accountable for their horribly irresponsible actions which resulted in all this suffering across the globe.
post 1687664663 08-02-2023, 04:52 PM
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#10
  1. x-trainer ben
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aww chit.

Mitochondrial dysfunction,
redox state imbalance,
impaired energy metabolism,
and chronic immune dysregulation
are likely to be the main hallmarks of long COVID even **two years after acute COVID-19 infection***."

that is pretty fkd up and explains an uncles taste and smell still being "off" after a long time.
There is an unspoken thing, we are iron brothers and sisters, we are to support each other and...It is our duty to support our brothers and sisters in the iron game!
post 1687664793 08-02-2023, 04:54 PM
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Originally Posted By x-trainer
aww chit.

Mitochondrial dysfunction,
redox state imbalance,
impaired energy metabolism,
and chronic immune dysregulation
are likely to be the main hallmarks of long COVID even **two years after acute COVID-19 infection***."

that is pretty fkd up and explains an uncles taste and smell still being "off" after a long time.
#JustTheSniffles
post 1687665423 08-02-2023, 05:06 PM
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#12
  1. x-trainer ben
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Originally Posted By J.L.C.⏩
#JustTheSniffles
Not for 2 fkn years it is not, cmon man!
There is an unspoken thing, we are iron brothers and sisters, we are to support each other and...It is our duty to support our brothers and sisters in the iron game!
post 1687665643 08-02-2023, 05:09 PM
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Demographic, clinical data and symptoms description

Table 1 shows baseline characteristics of patients enrolled in the study. Age was statistically different between negative (healthy) controls and COVID-19 patients. However, differences were not found in the self-reported comorbidities. Six patients (12.5%) developed mild disease; 37 patients developed (77%) moderate/severe disease while five patients (10.4%) developed critical disease. Six patients (12.5%) were reinfected during 2021 and 2022. All patients were fully vaccinated during the period of 2021–2022. Additional information from class A long COVID patients, class B long COVID patients, and recovered (non-long COVID) is provided in Supplementary Table 1.
Originally Posted By J.L.C.⏩
How does this study related to vaccines or vaccination? Can you get uninfected?
post 1687666313 08-02-2023, 05:22 PM
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Originally Posted By hackerwacker⏩
...
Yep. It doesn't look like the current vaccines protect against long covid.

(Repeated) infection is the concern
post 1687670773 08-02-2023, 06:40 PM
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Originally Posted By frankdtank20⏩
What he wrote went over your head.

Also, you're searching for attention. Nobody cares, including MDs.
The vaccine affected his focus
Would kick em in the nuts
post 1687671813 08-02-2023, 06:59 PM
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#16
  1. Dave22reborn
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Originally Posted By x-trainer
aww chit.

Mitochondrial dysfunction,
redox state imbalance,
impaired energy metabolism,
and chronic immune dysregulation
are likely to be the main hallmarks of long COVID even **two years after acute COVID-19 infection***."

that is pretty fkd up and explains an uncles taste and smell still being "off" after a long time.
Of course it does Benny, what a shocker thst you "know" someone suffering from "Long Covid."
post 1687671893 08-02-2023, 07:01 PM
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#17
  1. Dave22reborn
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You keep saying I shouldn't go to the hospital, but why shouldn't I? I may be suffering and not even know it......
post 1687673183 08-02-2023, 07:27 PM
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Originally Posted By Dave22reborn⏩
You keep saying I shouldn't go to the hospital, but why shouldn't I? I may be suffering and not even know it......
I don't think I've ever said you should or shouldn't do anything
post 1687673313 08-02-2023, 07:28 PM
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  1. J.L.C.
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Originally Posted By Antoine99⏩
The vaccine affected his focus
Frank won't be back ITT.
post 1687673853 08-02-2023, 07:39 PM
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Definitely not an engineered virus.
The Era of Great Noticing has begun.
Modern liberalism is morally bankrupt and demonic.
Right wing politics is the new counter-culture.
Wincel: "I'm saying even the govt of China, while brutal at times, is NOT our enemy. Period."
Has Beowulf10 ever experienced true love? Where did he go?
Education is humanity's key to salvation.
The 2nd Cold War has begun.
post 1687674623 08-02-2023, 07:54 PM
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Originally Posted By Dave22reborn⏩
Of course it does Benny, what a shocker thst you "know" someone suffering from "Long Covid."
I wish you had friends and family that liked or talked to you currently; then you would have a wider group of people, outside of Chicago, to make statements about.

i cant help it if your only "people" are the ones you work with while the rest of us normal people have family all over the world.

brain fog dave is gonna brain fog.
Maybe you are just not a friendly likeable individual.

Yes, 2 years later my uncle in phily has taste and smell that have not returned, the nerve was damaged.
There is an unspoken thing, we are iron brothers and sisters, we are to support each other and...It is our duty to support our brothers and sisters in the iron game!
post 1687674633 08-02-2023, 07:54 PM
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Originally Posted By XterraRob⏩
Definitely not engineered sniffles
Ftfy
post 1687679293 08-02-2023, 09:42 PM
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Originally Posted By J.L.C.⏩
#JustTheSniffles
Vax damage packaged as a psyop of "a virus".
Just saved a family members life by administering them dat dere "conspiracy theory horse paste", and other non-drugs unapproved by the white lab coat wearing drug cartel.

#dronestrikebigpharma
"The reason we are being murdered with genetic altering drugs is its slow acting and it causes your body to malfunction and destroy itself so there is a "plausible deniability" factor. Unlike most poisons which leave more evidence of being the direct cause of death."

1,151+ pages of peoples accounts of Covid-19 vaccine damage:
https://vestibular.org/forum/dizziness/covid-19-vaccine-side-effects/
post 1687679493 08-02-2023, 09:49 PM
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Ronaholic jabbie junkies like OP just can’t let it go & accept he got duped lol.
ANTI ANTIFA WORLDWIDE - DESTROY THE RED SCUM
post 1687680043 08-02-2023, 10:05 PM
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#25
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Coincel
Florida crew (lol at coldcels)
post 1687690903 08-03-2023, 05:09 AM
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#26
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Originally Posted By LizzieTish⏩
Vax damage packaged as a psyop of "a virus".
Just saved a family members life by administering them dat dere "conspiracy theory horse paste", and other non-drugs unapproved by the white lab coat wearing drug cartel.

#dronestrikebigpharma
But what about the damage from covid in unvaccinated people? It's difficult to blame a vaccine someone didn't receive.
post 1687691813 08-03-2023, 05:46 AM
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Originally Posted By x-trainer
I wish you had friends and family that liked or talked to you currently; then you would have a wider group of people, outside of Chicago, to make statements about.

i cant help it if your only "people" are the ones you work with while the rest of us normal people have family all over the world.

brain fog dave is gonna brain fog.
Maybe you are just not a friendly likeable individual.

Yes, 2 years later my uncle in phily has taste and smell that have not returned, the nerve was damaged.
Sure Benny, your uncle had nerve damage from Covid, that's a new one, juat like you "knew" someone who got the weakest variant, who was vaccinated, and she was bed ridden for 2 weeks.....

Just like you "know" a nurse who told you someone got Monkeypox, because he bumped into someone at a concert......
post 1687692063 08-03-2023, 05:52 AM
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#28
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MFC
Misc Cologne Crew | **BBC** | Aventus Friday Crew

RIP YGST
post 1687692203 08-03-2023, 05:55 AM
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Had it twice, I'll probably get it a third time since it's still out there, maybe I should mask up? Get vaccinated?
post 1687692453 08-03-2023, 06:03 AM
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#30
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Originally Posted By Dave22reborn⏩
Had it twice, I'll probably get it a third time since it's still out there, maybe I should mask up? Get vaccinated?
Some folks are okay with the risks of repeated infection, others aren't. Everybody's different
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