Acute blood biomarker profiles predict cognitive deficits 6 and 12 months after COVID-19 hospitalization


A study of unvaccinated people hospitalized with COVID-19 supports the theory that blood clots may contribute to later cognitive problems.


"Abstract

Post-COVID cognitive deficits, including ‘brain fog’, are clinically complex, with both objective and subjective components.

They are common and debilitating, and can affect the ability to work, yet their biological underpinnings remain unknown.

In this prospective cohort study of 1,837 adults hospitalized with COVID-19, we identified two distinct biomarker profiles measured during the acute admission, which predict cognitive outcomes 6 and 12 months after COVID-19.

A first profile links elevated fibrinogen relative to C-reactive protein with both objective and subjective cognitive deficits.

A second profile links elevated D-dimer relative to C-reactive protein with subjective cognitive deficits and occupational impact. This second profile was mediated by fatigue and shortness of breath.

Neither profile was significantly mediated by depression or anxiety.

Results were robust across secondary analyses. They were replicated, and their specificity to COVID-19 tested, in a large-scale electronic health records dataset.

These findings provide insights into the heterogeneous biology of post-COVID cognitive deficits.


https://www.nature.com/articles/s41591-023-02525-y

Oh yeah?

Gotta love studies reliant on pre-Omicron and all are people who were hospitalized. Nothing to do with the last 2 years of infections or healthy individuals.

I'm not sure the authors not addressing your specific research questions invalidates the study.

What should we do then? How should we live our lives?

Blood clots, you say? Hmm, now where have I heard about them, before, I wonder...

All subjects were unvaccinated.

Hmmm, no, that's not where I've heard that word before. Although, the last 10 letters of your sentence....thatdefinitely rings a bell!

Hard to blame something people didn't take.

Maybe they were all on birth control.

OP is only concerned with unvaccinated blood clots...

Who is it funded by so we can disregard any conclusions...lol

"This work was funded by MQ Mental Health Research, the Wolfson Foundation, UK Research and Innovation (grant MR/V027859/1), National Institute of Health Research (grant COV0319) and the National Institute for Health and Care Research (NIHR) Oxford Health Biomedical Research Centre (grants BRC-1215-20005 and NIHR203316). M.T. is an NIHR Academic Clinical Fellow and NIHR Oxford Health BRC Senior Research Fellow. The authors acknowledge the eDRIS team (Public Health Scotland) for their support in obtaining approvals, the provisioning and linking of data and facilitating access to the National Safe Haven and N. Curry for valuable input. P.J.H. and M.T. were granted unrestricted and free access to the TriNetX Analytics Network, with no constraints on the analyses done nor the decision to publish. The views expressed are those of the authors and not necessarily those of the UK NHS, the NIHR or the UK Department of Health. L.P.H. is supported by the NIHR Oxford Biomedical Research Centre."

This. Might as well post the statistics on sabertooth tiger attacks.


Also:



1: mRNAs are not vaccines in any traditional sense. They work in a very different way.

2: Before 2020 mRNA biotechnology was - at best - several years from use outside clinical trials. The scientists working on it were struggling with the risks of repeated dosing.

3: The two large clinical trials in 2020 from Pfizer and Moderna that led to the approval of the mRNAs did NOT show that they reduced deaths from Covid, or from other causes.

4: The clinical trials showed the mRNAs caused more and more severe side effects than most traditional vaccines, especially flu shots. Real-world experience confirmed the trial findings.

5: The major clinical trials were effectively stopped in early 2021, and as a result we do not have long-term placebo-controlled safety data on the mRNAs.

6: We also do not have long-term controlled data on their effectiveness. This gap matters less, though, since everyone now agrees that - at best - they worked against Covid infection or transmission for a few months in 2021.

7: The evidence health authorities offer for their claims that the shots work against severe disease and death - even after they fail against infection - comes from “observational” studies. Those are hopelessly untrustworthy. The reason is that people are generally not vaccinated if they are on or near their deathbeds - and terminally ill people are obviously at very high risk of death from all causes, including Covid.
In essence, the people who receive vaccinations cannot be compared to those who do not. Health authorities are well aware of this issue, but they ignore it, because it enables them to claim the vaccines work.

8: The mRNAs appear to have zero or negative effectiveness against Omicron infection. Negative effectiveness means they may actually increase the risk of infection. Some studies show that the infection risk RISES with each additional dose.

9: Data from many countries that used mRNAs shows the booster campaigns in early 2022 and late 2022/early 2023 coincided with increases in all-cause deaths. This correlation is particularly striking in the second campaign, because it cannot be attributed to Covid.

Kinda disappointing copy/paste is all you have, tbh

Thus the recent shrieking is a true grass-roots (or maybe more accurately Twitter-roots) phenomenon.

At its heart is a small but loud group of very online folks who cannot stand the fact that the world has moved on from Covid. They feel increasingly ostracized over their mask-wearing, whining about ventilation, and demands for never-ending free tests and vaccines.

In reality, almost no one cares enough to judge them, a fact that bothers them even more.

Even worse, many of them are “disabled” as a result of “long Covid” and do not work, giving them even more time to wind each other up. Since 2021, they have desperately hoped for validation for long Covid.

But the $1 billion long Covid research slush fund they convinced the National Institutes of Health to set up is almost gone, with no signs of progress. (It’s hard to solve a disease that exists mostly entirely in the minds of its sufferers when the first rule of research is pretending the disease isn’t ****tic.)

For the long Covidians, illness is ideology - as well as a pocketbook issue. The murkier long Covid is as an illness, the more resistance their disability applications will face.

No accident, then, that the recent warnings often prominently feature the \dangers of long Covid. (Highlighting long Covid also helps gloss over the mildness of Covid itself, a crucial step given that almost everyone has now had the virus and can no longer be terrified with tales of blood clots and sudden death.)
—
Meanwhile, though Democratic politicians want nothing to do with Covid 2.0 (3.0?) , their usual allies in the elite media have proven only too willing to amplify the recent Twitter freakouts.
After all, the Times and similar woke outlets don’t have elections to win. They cater to an increasingly narrow slice of the population that includes essentially everyone who is predisposed to believe the worst about long Covid. Not a few of their writers are long Covidians too.

And so the Times, CNN, and the rest have all dutifully reported on the new wave. They haven’t forgotten to mention long Covid, either.

“Every time you get infected, no matter the severity, there is always a chance that you can develop longer-term symptoms,” the Times wrote today in a story about reinfections.

As for what they want?

They want what they’ve wanted from the start of Covid. They want what they always want. They want everyone to be scared. They want free stuff.

Most of all, they want you to listen.


And obey.

Not even gonna give the author credit?

OP really doesn't want to move on from 2020....

Why not?

Why should we still pretend it's 2020????

I don't think we should.

And yet you still wear a mask, and want everyone to take mitigation measures.....

Mask up. Inside your home And out.

What % of people with “long covid” are vaccinated?

Most important, it's about getting paid $$$.

No one:

OP: 500th thread on how he is trying to convince himself he made the right decision to get vaccinated

This study has nothing to do with vaccination.

It's just that the cohort removes the option of blaming vaccines.

Were they "fully" vaccinated?

In this study - 0%