Is OP a COVID cheerleader or wat

How so?

i first heard about it from powerlifter/bodybuilder Stan Efferding, and how D is a hormone not just a vitamin supplement.
glad your program has worked for you.

Like BrooksKoepa is about that Katy chick in main misc. Bustin all kinds of nuts to it

Points worth considering, for sure!

Another excellent point!

Maybe autoimmune disorders are nbd?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10222767/


Additionally, recent investigations have found abnormally high levels of IgG4 in people who were administered two or more injections of the mRNA vaccines. HIV, Malaria, and Pertussis vaccines have also been reported to induce higher-than-normal IgG4 synthesis. Overall, there are three critical factors determining the class switch to IgG4 antibodies: excessive antigen concentration, repeated vaccination, and the type of vaccine used. It has been suggested that an increase in IgG4 levels could have a protecting role by preventing immune over-activation, similar to that occurring during successful allergen-specific immunotherapy by inhibiting IgE-induced effects. However, emerging evidence suggests that the reported increase in IgG4 levels detected after repeated vaccination with the mRNA vaccines may not be a protective mechanism; rather, it constitutes an immune tolerance mechanism to the spike protein that could promote unopposed SARS-CoV2 infection and replication by suppressing natural antiviral responses. Increased IgG4 synthesis due to repeated mRNA vaccination with high antigen concentrations may also cause autoimmune diseases, and promote cancer growth and autoimmune myocarditis in susceptible individuals.



This research received no external funding.


The authors declare no conflict of interest.

What the skeptics fail to elucidate is why non-inflammatory neutralizing antibodies are bad.

It's not a full class switch. The IgG3 is still the majority.

Class switch towards spike protein-specific IgG4 antibodies after SARS-CoV-2 mRNA vaccination depends on prior infection history

"The pattern of spike-specific IgG subclasses in individuals infected before mRNA vaccinations resembled that of vector-vaccinated subjects or unvaccinated COVID-19 patients. However, the pattern of mRNA-vaccinated individuals without SARS-CoV-2 preinfection showed a markedly different pattern. In addition to IgG1 and IgG3 subclasses presented in all groups, a switch towards distal IgG subclasses (spike-specific IgG4 and IgG2) appeared almost exclusively in individuals who received only mRNA vaccines or were infected after mRNA vaccinations. In these subjects, the magnitude of the spike-specific IgG4 response was comparable to that of the spike-specific IgG1 response.

These data suggest that the priming of the immune system either by natural SARS-CoV-2 infection or by vector- or mRNA-based vaccinations has an important impact on the characteristics of the developed specific humoral immunity."

"Furthermore, high levels of IgG4 expression can appear after allergen-specific immunotherapy43 or in several types of cancers44, which is beneficial in allergic diseases but may indicate impaired humoral immunity to tumors. Prior to the COVID-19 pandemic, mRNA technology was mostly developed as a novel cancer therapy. For cancer therapies, such as melanoma, glioblastoma, colorectal cancer, and prostate cancer; the mRNA vaccine candidates are still in clinical trials45. Immune memory and the generation of specific class-switched antibodies are mainly dependent on T-cell responses. Robust and persistent follicular helper T-cell (Tfh) response has also been described in lymph nodes of individuals vaccinated by Pfizer-BioNTech vaccine46. Further analysis of Tfh cells in lymph nodes may play a crucial role in the effectiveness of mRNA-based vaccinations."

"Conclusions

In summary, our data presented here are a highly relevant confirmation of previous findings that mRNA vaccinations induce high proportion of spike-specific IgG4 antibody responses. In contrast, individuals vaccinated with mRNA vaccines after SARS-CoV-2 infection, as well as naïve individuals vaccinated with vector-based vaccines did not develop significant IgG4 isotyped spike-specific response. Further studies are needed to clarify the relevance of our findings for future mRNA-based vaccine development."


https://www.nature.com/articles/s41598-023-40103-x

Funding
Open access funding provided by Semmelweis University. Project No. TKP2021-EGA-24 (MOLORKIV) has been implemented with the support provided by the Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund, financed under the TKP2021-EGA funding scheme, by the Higher Education Institutional Excellence Program of the Ministry of Human Capacities in Hungary, within the framework of the molecular biology thematic program of Semmelweis University, and by the National Research, Development and Innovation Office (2020-1.1.6-JOVO-2021-00013 to ZP).

Ethics declarations
Competing interests
The authors declare no competing interests.

I took vitamin D once and it gave me the shjtz.

Ono!

Did you try ivermectin?

Nope, why would I?

Tell the truth.. The Rona and Ivermectin together in the same sentence pisses you off so bad that you want to throw down on a motherfuker, doesn't it.

Not at all. Why would it?

Because! Your Rona and the sacred Fauci Fluid is to be defended at all costs god dammit!