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Forum » COVID vaccine might lead to ADE
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Thread: COVID vaccine might lead to ADE

post 1645630583 08-24-2021, 02:03 PM
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COVID vaccine might lead to ADE

This paper below out of Japan suggests the COVID vaccine will potentially lead to ADE

Anti body dependent is your body producing an over reaction to different variants of the virus.

https://www.biorxiv.org/content/10.1...114v1.full.pdf
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post 1645630773 08-24-2021, 02:06 PM
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Many doctors suggest we are already seeing ADE.

From the pdf in OP.
Abstract:

mRNA-based vaccines provide effective protection against most common SARS-CoV-2 variants. However,
identifying likely breakthrough variants is critical for future vaccine development. Here, we found
that the Delta variant completely escaped from anti-N-terminal domain (NTD) neutralizing
antibodies, while increasing responsiveness to anti-NTD infectivity-enhancing antibodies. Although
Pfizer-BioNTech BNT162b2-immune sera neutralized the Delta variant, when four common mutations were
introduced into the receptor binding domain (RBD) of the Delta variant (Delta 4+), some
BNT162b2-immune sera lost neutralizing activity and enhanced the infectivity. Unique mutations in
the Delta NTD were involved in the enhanced infectivity by the BNT162b2-immune sera. Sera of mice
immunized by Delta spike, but not wild-type spike, consistently neutralized the Delta 4+ variant
without enhancing infectivity. Given the fact that a Delta variant with three similar RBD mutations
has already emerged according to the GISAID database, it is necessary to develop vaccines that
protect against such complete breakthrough
variants.
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post 1645631643 08-24-2021, 02:17 PM
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Originally Posted By keyboardworkout⏩
Many doctors suggest we are already seeing ADE.

From the pdf in OP.
"Given the fact that a Delta variant with three similar RBD mutations has already emerged according to the GISAID database, it is necessary to develop vaccines that protect against such complete breakthrough variants."

Just mentioned here in a thread this morning.

There was concern about the potential for ADE from the start, but the data looked good for a while. Now this is may be the first official paper stating it could be happening.

No one has wanted to crawl out on that limb. Probably because if you are wrong your public life and career are likely over. And if you are right then you aren't likely to be too popular either for revealing an unfolding CF of history making proportions.
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post 1645631933 08-24-2021, 02:21 PM
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whats ade?
post 1645632023 08-24-2021, 02:21 PM
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lmao the increase of 911 calls the media is trying to portray as unvaxxed kung flu related is ADE.
post 1645632083 08-24-2021, 02:22 PM
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Think I'll wait for a summary from an expert instead of trying to read that study.

Will be interesting to see what comes of it.
Originally Posted By TurkBrah⏩
whats ade?
Antibody dependant enhancement. In this case the vaccine would cause your immune system to go haywire and attack your own lungs if you got infected with the actual virus.
post 1645632113 08-24-2021, 02:22 PM
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Originally Posted By TurkBrah⏩
whats ade?
this lol

edit: it looks like some sort of aids
post 1645632303 08-24-2021, 02:25 PM
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all miscers are vaxxed why do you think we're so autistic?
post 1645633193 08-24-2021, 02:34 PM
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So if I already had the coof, and 1 shot of pfizer how ****ed am I?
post 1645633333 08-24-2021, 02:35 PM
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Originally Posted By Underwrought⏩
So if I already had the coof, and 1 shot of pfizer how ****ed am I?
Probably safe since you already have natural immunity. It's the pure vaccinecells that are screwed if ADE turns out to be a problem.

Why you would take the vaccine when you've already had covid is beyond me though.
post 1645633513 08-24-2021, 02:38 PM
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Originally Posted By Azure84⏩
Probably safe since you already have natural immunity. It's the pure vaccinecells that are screwed if ADE turns out to be a problem.

Why you would take the vaccine when you've already had covid is beyond me though.
My work threatened us. Stopping at one though. Unless they literally force me to take it.
post 1645633743 08-24-2021, 02:40 PM
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ADE occurs when the antibodies generated during an immune response recognize and bind to a pathogen, but they are unable to prevent infection. Instead, these antibodies act as a “Trojan horse,” allowing the pathogen to get into cells and exacerbate the immune response.
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post 1645633903 08-24-2021, 02:41 PM
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Originally Posted By TurkBrah⏩
whats ade?
Cliffs: Your own immune system goes haywire, all kinds of autoimmune issues, often death (at least in many animal trials for other covid mRNA vaccines from 2006-2016)

^ ignore, read the post below, i was confused with something else (another potential problem but not the one we are discussing)
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post 1645633913 08-24-2021, 02:42 PM
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Posted this before I think. Article from December 2020:
The simple definition of ADE is “raising antibodies that don’t protect, but actually make a viral infection even worse”. And obviously, that’s the opposite of what you want.
So there are plenty of ways to get neutralizing antibodies, with various ways of binding to the Spike protein and in binding to other coronavirus proteins as well. But there are also plenty of ways to get non-neutralizing antibodies, ones that stick to some part of the coronavirus particle without really inconveniencing it much. That’s obviously useless, andantibody-dependent enhancement takes things down another notch, from useless to outright harmful. With ADE, the binding of such an antibody actually assists the virus, by [for example] actually making it easier for the virus to get taken up through the outer membranes of human cells. Another possibility is that an antibody that would be neutralizing if present in sufficient amounts can actually enhance infection in lower dilutions, which has been seen with influenza antibodies and other viruses as well. This seems to be through aggregation of viral particles, although other factors might be at work.

You really don’t want ADE through any of these mechanisms – bad things happen.
...you’ll be glad to hear that the news starts to improve at this point. For one thing,the current coronavirus does not seem to productively infect macro****es, which are by far the main target for that antibody-receptor-uptake ADE mechanism. The related MERS coronavirus was able to do this, but not SARS-CoV-2, fortunately. So the two mechanisms seen in [for example] dengue do not seem to be as much of a worry.The complement-driven stuff is still on the table, though, and indeed matches up well with the “cytokine storm” lung damage seen in severe patients.

But as that new paper says, thus far“No definitive role for ADE in human coronavirus diseases has been established.”That may be a bit surprising, if you’ve been seeing worried stories about antibody-dependent enhancement over the last few months.That doesn’t mean that ADE can’t be operating, of course, just that we don’t have the solid evidence that it is.
Some of the earlier attempts at a SARS vaccine showed ADE effects in mouse models, and further work showed that this seemed to be linked not so much to the antibody response as to the T cell response. Specifically, a “Th2” heavy response [as opposed to more Th1 or a balance between the two], was linked to lung pathology. Those are subdivisions of the CD4+ T cells, based on which cytokines they produce, and these results alerted everyone to keep an eye out for that.
At this point, I would say thatthe main worry for any ADE effects would be if the coronavirus mutates to the point that the antibodies generated by the current vaccines become non-neutralizing.
https://blogs.sciencemag.org/pipelin...nt-enhancement
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post 1645636313 08-24-2021, 03:08 PM
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I like how probably one of the more important threads created, maybe ever, in the misc gets bumped to page 2 so that threads with kiop posting his gif or pictures of fat nerds with plastic freaky wives and chit make page 1.
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post 1645637623 08-24-2021, 03:23 PM
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Originally Posted By InVentive44⏩
This paper below out of Japan suggests the COVID vaccine will potentially lead to ADE

Anti body dependent is your body producing an over reaction to different variants of the virus.

https://www.biorxiv.org/content/10.1...114v1.full.pdf
study is a preprint and not reviewed yet, so it's a bit early to be jumping to conclusions and spreading misinformation.

Until this study is peer reviewed, I'll stick with this analysis over the very limited data we do have:

https://www.deplatformdisease.com/bl...ll-no-evidence
post 1645637753 08-24-2021, 03:24 PM
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Originally Posted By JUSA⏩
I like how probably one of the more important threads created, maybe ever, in the misc gets bumped to page 2 so that threads with kiop posting his gif or pictures of fat nerds with plastic freaky wives and chit make page 1.
To be fair it's a 31 page study and not a single miscer will understand any of it unless they put a LOT of effort into reading it. It will be interesting once it gets noticed and reviewed though.
post 1645637853 08-24-2021, 03:26 PM
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Originally Posted By Underwrought⏩
My work threatened us. Stopping at one though. Unless they literally force me to take it.
Why would you let your employer, that literally doesn’t give 2 chits about you and would replace you in a heartbeat, coerce you into getting a jab?
Age: 30

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post 1645638043 08-24-2021, 03:28 PM
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no no no... not THAT science.
post 1645638053 08-24-2021, 03:28 PM
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Originally Posted By BeginnerGainz⏩
Why would you let your employer, that literally doesn’t give 2 chits about you and would replace you in a heartbeat, coerce you into getting a jab?
Because soon you won't be able to buy, work or live without complying.

Textbook end of times antichrist stuff.
post 1645638563 08-24-2021, 03:34 PM
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Originally Posted By JUSA⏩
I like how probably one of the more important threads created, maybe ever, in the misc gets bumped to page 2 so that threads with kiop posting his gif or pictures of fat nerds with plastic freaky wives and chit make page 1.
Ignorance is bliss, brother. Most people I speak to don't want to know about possible repercussions. They would rather follow their government and roll the dice with the vaccine than confront the possible dangers and actually have to think critically.
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post 1645639263 08-24-2021, 03:44 PM
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Originally Posted By BeginnerGainz⏩
Why would you let your employer, that literally doesn’t give 2 chits about you and would replace you in a heartbeat, coerce you into getting a jab?
This

If the first jab killed you, your position would be advertised before your even cold.
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