What, if any, supplements do you use that you can't believe aren't universal?

Was talking to someone online recently about supplements, medications and he was talking about how his doctor had prescribed him some weight-loss drug that was working incredibly well for him and he'd lost loads of weight over the course of a couple months, and that he didn't understand why stuff like it wasn't more freely available/widely prescribed.

With that said I've lately been wondering - what simple, over-the-counter/easily available stuff is there that people could take which could noticably improve their life?

I've been aware of Vit D and fish oil for years, but it's got me wondering if there's other things that come with benefits, which you'd think would be used by everyone, everyday, but just aren't.