Just wanted to remind you.

A mitochondrion (/ˌmaɪtəˈkɒndriən/;[1] pl.: mitochondria) is an organelle found in the cells of most eukaryotes, such as animals, plants and fungi. Mitochondria have a double membrane structure and use aerobic respiration to generate adenosine triphosphate (ATP), which is used throughout the cell as a source of chemical energy.[2] They were discovered by Albert von Kölliker in 1857[3] in the voluntary muscles of insects. The term mitochondrion was coined by Carl Benda in 1898. The mitochondrion is popularly nicknamed the "powerhouse of the cell", a phrase coined by Philip Siekevitz in a 1957 article of the same name.[4]


Two mitochondria from mammalian lung tissue displaying their matrix and membranes as shown by electron microscopy
Some cells in some multicellular organisms lack mitochondria (for example, mature mammalian red blood cells). The multicellular animal Henneguya salminicola is known to have retained mitochondrion-related organelles in association with a complete loss of their mitochondrial genome.[5][6][7] A large number of unicellular organisms, such as microsporidia, parabasalids and diplomonads, have reduced or transformed their mitochondria into other structures,[8] e.g. hydrogenosomes and mitosomes.[9] The oxymonads Monocercomonoides, Streblomastix, and Blattamonas have completely lost their mitochondria.[5][10]

Mitochondria are commonly between 0.75 and 3 μm2 in cross section,[11] but vary considerably in size and structure. Unless specifically stained, they are not visible. In addition to supplying cellular energy, mitochondria are involved in other tasks, such as signaling, cellular differentiation, and cell death, as well as maintaining control of the cell cycle and cell growth.[12] Mitochondrial biogenesis is in turn temporally coordinated with these cellular processes.[13][14] Mitochondria have been implicated in several human disorders and conditions, such as mitochondrial diseases,[15] cardiac dysfunction,[16] heart failure[17] and autism.[18]

The number of mitochondria in a cell can vary widely by organism, tissue, and cell type. A mature red blood cell has no mitochondria,[19] whereas a liver cell can have more than 2000.[20][21] The mitochondrion is composed of compartments that carry out specialized functions. These compartments or regions include the outer membrane, intermembrane space, inner membrane, cristae, and matrix.

Although most of a eukaryotic cell's DNA is contained in the cell nucleus, the mitochondrion has its own genome ("mitogenome") that is substantially similar to bacterial genomes.[22] This finding has led to general acceptance of the endosymbiotic hypothesis - that free-living prokaryotic ancestors of modern mitochondria permanently fused with eukaryotic cells in the distant past, evolving such that modern animals, plants, fungi, and other eukaryotes are able to respire to generate cellular energy.[23]